41st Symposium: Splicecon

All times in Madison, US Central Time
Invited Talks = 20 min followed by 10 min Q&A
Selected Talks = 10 min followed by 5 min Q&A

Thursday April 22

9:00-9:45am Keynote Talk, Holger Stark
Structural Dynamics of pre-mRNA Splicing
9:45-10:00am Q & A

Session 1:  Spliceosome Structure

10:00-10:20am   Invited Talk 1 – Sebastian Fica
Structural basis for conformational equilibrium of the catalytic spliceosome

10:30-10:50am   Invited Talk 2 – Vlad Pena
Selection of introns by U2 snRNP in the presence of covalent modulators

11:00-11:10am   Selected Talk 1 – Alexandra Bergfort
The C9ORF78 protein interactions with human BRR2 and regulates alternative splicing of specific pre-mRNAs

11:15-11:30am   Video 1 of Poster Presenters Giving Flash/Lightning Talks

11:30-12:30pm   Poster Session 1

BREAK

Session 2: Spliceosome Mechanism

1:00-1:20pm   Invited Talk 3 – Jon Staley
Profiling nascent lariat intermediates reveals the genomic basis of splicing timing

1:30-1:50pm   Invited Talk 4 – Al Zahler
The Chain of Custody-Genetic Examination of the Precise Transfer of Splice Sites into the Catalytic Core of the Spliceosome

2:00-2:10pm   Selected Talk 2 – Ian Eperon
Exon-independent recruitment of SRSF1 is mediated by U1 snRNP stem-loop 3

2:15-2:30pm   Video 2 of Poster Presenters Giving Flash/Lightning Talks

BREAK

3:00-4:00pm   Panel Discussion on Splicing, Technology, Inclusion, & the Future
Tracy Johnson; Karla Neugebauer; Manny Ares; Jeff Pleiss

4:00-7:00pm   Social Time

Friday April 23

Session 3: Alternative Splicing

9:00-9:20am   Invited Talk – Florian Heyd
Body temperature-controlled alternative splicing: The role of kinases, phosphatases, and a connection to cancer

9:30-9:50am   Invited Talk 6 – Kristen Lynch
Alternative Splicing and the Immune System

10:00-10:10am   Selected Talk 3 – Ana Fiszbein
Widespread usage of hybrid exons in human transcriptomes

BREAK

Session 4: Splicing in Disease

10:30-10:50am   Invited Talk 7 – Olga Anczuków
Misregulation of Splicing Factors in Breast Tumors

11:00-11:20am   Invited Talk 8 – Esther Obeng
Spliceosome Mutations in Myelodysplastic Syndromes and Leukemia

11:30-11:40am   Selected Talk 4 – Ray O’Keefe
A patient cell model for probing reduced spliceosome snRNP protein expression in disease

11:45-11:55am   Selected Talk 5 – Jagjit Singh
Modeling microcephaly in patient iPS cell-derived brain organoids with U4atac snRNA mutations

12:00-12:15   Video 3 of Poster Presenters Giving Flash/Lightning Talks

BREAK

12:45-1:45pm   Poster Session 2

Session 5: Splicing Therapies

1:45-2:05pm   Invited Talk 9 – Clara Kielkopf
Targeting U2AF: An Achilles’ Heel of Myelodysplastic Syndromes?

2:15-2:25pm   Selected Talk 6 – Irene Beusch
Base editing the human spliceosome in haploid cells reveals a role for SUGP1 in drug resistance

2:30-2:50pm   Invited Talk 10 – Melissa Jurica
It Takes More than Binding: Probing SF3B Inhibitor Mechanism

Session 6: Spliceosome Evolution

3:00-3:20pm   Invited Talk 11 – Nav Toor
Retroelement origins of pre-mRNA splicing

3:30-3:50pm   Invited Talk 12 – Scott Roy
Splicing: the last two billion years

BREAK

4:30-6:00pm   Poster Session 3

6:00-8:00pm   Social Time

Aaron Hoskins

Samuel Butcher

David Brow