39th Symposium: Iron-Sulfur Proteins—Biogenesis, Regulation and Function

May 29 through June 2, 2018 at Memorial Union

This international meeting is the latest in a series that convened last in Bergamo, Italy in 2015. The symposium will bring together leading scientists in the field of iron–sulfur proteins to discuss their most recent research activities.

Fe–S cluster assembly and transfer
Compartmentalization of Fe–S protein biogenesis
Assembly of clusters in multisubunit complexes
Iron trafficking, regulation, and sensing
Regulation of Fe–S protein biogensis
Disease-associated Fe–S protein defects
Fe–S proteins: atypical clusters, novel chemistry, and new roles and functions
Engineering and evolution of Fe–S proteins

Registration

To register, please click here: 39th Steenbock Symposium Registration Form
The Registration fee includes admission to the talks and poster sessions, the program book, a welcome reception, lunches, breaks, and the banquet.

Registration will close on 5/28/2018

Fees and Deadlines
Student Registration: $200
Early Non-Student Registration (before April 15): $400
Non-Student Registration (after April 15): $450

Cancellation Policy
A registration refund, minus a $75 administrative charge, will be made for cancellation requests received on or before May 15, 2018. No refunds will be given after May 15, 2018. Substitute registrations are accepted. Contact Wisconsin Union Conference Management at 608-265-6534 or email steenbock39@union.wisc.edu. Contact WU Conference Management to request a refund. WU Conference Management may require up to 10 business days to process and issue a refund.

Registration Questions
Please call WU Conference Management at 608-265-6534 or email steenbock39@union.wisc.edu

Abstract Guidelines

Abstract deadline is April 15, 2018

Please submit your abstract at:
https://uwmadison.eventsair.com/steenbock39/abstract

Before beginning your submission, please collect the following

• Presenting author’s contact information and affiliation

• Co-authors names and affiliations

• Principal Investigator/Lab Head name and affiliation

Abstract Submission Guidelines

• Be sure to include all authors in the author list, including the submitting author, any co-authors, and Principal Investigator/Lab Head

• Abstract length is limited to 2500 characters

• One abstract will be allowed per registrant

• All abstracts must be submitted and presented in English with a quality of spelling and grammar suitable for publication

• All submissions will print the exact way they are submitted

Review Procedures

• Abstracts must be received by April 15 to be considered for an oral presentation

• All submittals are reviewed by the Scientific Organizing Committee

• Proposals constituting sales pitches for products or services will not be considered

• Complete presentation instructions will be emailed to accepted submitters

• Any oral presentations not chosen for an oral presentation will receive a poster presentation

Poster Info

Maximum size: 4 ft (122 cm) x 4 ft (122 cm)

Pins will be provided.

Posters should be set up before 2:00 PM on Wednesday, May 30th.

Posters must be taken down by 3:30 PM on Saturday, June 2nd.

— LIGHTNING PRESENTATIONS – Pre-Poster Sessions 1 & 2 —

“To promote the research that will be presented during the poster sessions, we have scheduled time right before each of the first two poster sessions for lightning poster presentations. If you choose to participate, poster presenters should prepare 1 slide to present a 1 min highlight of their poster findings. The author should focus only on the main aim of the research and the major findings since the purpose of a “lightning presentation” is to give the audience the “major take-home message” from your poster, NOT to present all of the results. These presentations should stimulate the audience to view the poster and to discuss the research with the author during the breaks or poster session.

Email your one summary slide to steenbock39@union.wisc.edu by Tuesday, May 22nd, by 5pm.”

Schedule

Meeting Schedule

Tuesday, May 29, 2018
Arrival
5:00 pm – 7:30 pm Registration and reception (Shannon Sunset Lounge, Memorial Union)
Excursion sign-up

7:30 pm – 8:30 pm Keynote lecture: (Shannon Hall) (Chair: John Markley)
Roland Lill: Biogenesis of Iron-Sulfur Proteins in Eukaryotes: Components, Mechanisms, and Diseases

8:30 pm – 10:00 pm Cash bar on Sunset Deck-Upper:

Wednesday, May 30, 2018
Session 1: 9:00 am – 10:30 am (chair: Perry Frey)
9:00 am     Joan Broderick: A New Paradigm for Radical SAM Reactions
9:30 am Squire Booker: A Saga of Death, Destruction, and Rebirth: the Role of Iron-Sulfur Clusters in the Biosynthesis of Lipoic Acid
10:00 am   Catharina M. Blinn: Apd1 and Aim32 are Prototypes of a New Class of [2Fe-2S] Proteins
10:15 am   Vikas Nanda: Design of a Primordial Ferredoxin
Break: 10:30 – 11:00 am
Session 2: 11:00 am – 12:30 pm (chair:  Dennis Dean)
11:00 am   Lance Seefeldt: Energy Transduction in Nitrogenase
11:30 am   Brian Hoffman: The Mechanism of Nitrogen Fixation by Nitrogenase
12:00 n    Lightning poster talks (odd numbered)
Lunch: 12:30 pm – 2:00 pm (food served outside Shannon Hall, take to Tripp Commons/Deck; dessert in Tripp)
Poster session 1: 2:00 pm – 4:00 pm (Tripp Commons)
Session 3: 4:00 pm – 6:00 pm (chair: Patricia Dos Santos)
4:00 pm Yasuhiro Takahashi: Novel Insights into Bacterial Iron–Sulfur Cluster Biosynthesis Systems
4:30 pm Sandrine Ollagnier: Mechanistic Investigations on the Fe-S Cluster Assembly by the SUF Machinery
5:00 pm F. Wayne Outten: Exploring Interactions between the Suf Fe-S Cluster Biogenesis Pathway, Fe-S Cluster Trafficking Networks, and Iron Homeostasis in E. coli
5:30 pm Patrick A. Frantom: Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems
5:45 pm Vojtech Vacek: Fe-S Cluster Assembly in Oxymonads and Related Protists

Thursday, May 31, 2018
Session 4: 9:00 am – 10:30 am (chair: Timothy Stemmler)
9:00 am Miroslav Cygler: Structure and Dynamics of the Core Fe/S Cluster Assembly Complex
9:30 am Marco Tonelli: Fluorine-19 NMR Investigations of Steps in Iron-Sulfur Cluster Assembly
9:45 am Hélène Puccio: Therapeutic Development for Friedreich Ataxia: Replacing or Bypassing Frataxin?
10:15 am Paul Lindahl: Analysis of Mrs3ΔMrs4Δ and Yfh1Δ Saccharomyces cerevisiae, and the Role of Fe580

Break: 10:30 – 11:00 am
Session 5: 11:00 am – 12:30 pm (chair: Jin Hae Kim)
11:00 am   David Barondeau: Elucidating Control Mechanisms for the Eukaryotic Fe-S Cluster Biosynthetic Complex
11:30 am   Dennis Winge: The Mitochondrial Acyl Carrier Protein Acp1 Coordinates Mitochondrial Fatty Acid Synthesis with Iron Sulfur Cluster Biogenesis
11:45 am   Trey Sato: Directed Evolution uncovers Mutations in Fe-S Cluster Biogenesis Genes that Enable Anaerobic Xylose Fermentation by Saccharomyces cerevisiae
12:15 pm   Benoit D’autréaux: Insight into the Primary Steps of Fe-S Cluster Assembly by the ISC Machinery
Box Lunches: 12:30 pm (food can be eaten on the Terrace or in Tripp Commons)

Free afternoon and evening

Friday, June 1, 2018
Session 6: 9:00 am – 10:30 am (chair: Joff Silberg)
9:00 am Lucia Banci: Structural and Functional Characterization of Processes for FeS protein Biogenesis
9:30 am Jaroslaw Marszalek: Hsp70 Chaperone Systems in Iron-Sulfur Cluster (FeS) Biogenesis
10:00 am   Ian Campbell: Evolutionary Relationships between Low Potential Electron Carriers that use 2Fe-2S, 4Fe-4S, and Flavin Mononucleotide Cofactors
10:15 am   Giovanna Ghirlanda: Artificial Iron-Sulfur Proteins for Electron Transfer and Catalysis
Break: 10:30 – 11:00 am
Session 7: 11:00 am – 12:30 pm (chair: Brian Fox)
11:00 am   Jared Rutter: Coordinate Regulation of OXPHOS Biogenesis
11:30 am   Nicolas Rouhier: Functional Characterization of Mitochondrial NFU Proteins in Plants
12:00 n   Lightning poster talks (even numbered)
Lunch: 12:30 pm – 2:00 pm
Committee meeting: CapView Room, 4th floor Memorial Union
Poster session 2: 2:00 pm – 4:00 pm
Session 8: 4:00 pm – 6:00 pm (chair: Beatrice Py)
4:00 pm Dennis Dean: Sequential and Differential Interaction of Assembly Factors during Nitrogenase MoFe Protein Maturation
4:30 pm Michael K. Johnson: Scaffold-Free Fe-S Cluster Assembly using a Thioferrate-Protein Nanoparticle
4:45 pm Silke Leimkühler: Shared Sulfur Mobilization Routes for Fe-S Cluster Assembly and Molybdenum Cofactor
Biosynthesis in Escherichia coli
5:15 pm Frédéric Barras: FeS under Stress: Acting at all Stages of Production
5:45 pm Patricia Dos Santos: Redox Regulation involving Bacillus subtilis Thioredoxin and Fe-S Clusters

Saturday, June 2, 2018
Session 9: 9:00 am – 10:30 am (chair: Jeff Boyd)
9:00 am Nick Le Brun: Studies of Iron-Sulfur Cluster Reactivity by Mass Spectrometry
9:30 am Jim Imlay: Iron-Sulfur Enzymes Lie at the Heart of the Oxygen Sensitivity of an Obligately Anaerobic Bacterium
10:00 am   Rebekah M.B. Silva: UvrC Coordinates a Redox-Active 4Fe-4S Cluster Critical for Stability and Function
10:15 am   Dror Noy: CCIS1, a Computationally Designed Protein Expressed in E. coli, and Assembled in vivo as an Iron Sulfur Cluster with a Non-natural Fold
Break: 10:30 – 11:00 am
Session 10: 11:00 am – 12:30 pm (chair: Rick Eisenstein)
11:00 am   Deborah Perlstein: CIA Secrets Revealed: Dre2 and Nar1 Collaborate with the Nbp35-Cfd1 Scaffolding Complex During the Early Steps of Cytosolic Iron Sulfur Cluster Assembly
11:30 am   P. Ryan Potts: Cytosolic Iron-Sulfur Assembly is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase
11:45 am   Carina Greth: Molecular Determinants for Cytosolic Iron-Sulfur Cluster Insertion
12:00 n   Joseph J. Braymer: The Contribution of Thiol Redox Chemistry to Mitochondrial and Cytosolic Iron-Sulfur Cluster Biogenesis
12:15 pm   Xiaokang Wang: A linker-Targeted sgRNA Reveals Canonical and Non-canonical Function of DRE2
Lunch: 12:30 pm Box lunches (food can be eaten on the Terrace or in Tripp Commons)
Poster session 3: 2:00 pm – 3:30 pm (Tripp Commons)
Remove posters: 3:30
Session 11: 4:00 pm – 6:00 pm (chair: George Reed)
4:00 pm Caroline C Philpott: Distributing Iron in Cells: BolA2 Links PCBP1-Bound Ferrous Iron to the 2Fe-2S Distribution System
4:15 pm Jorge L. Porfido: Unique Features of an Unusual Parasite Thioredoxin
4:30 pm Rick Eisenstein: A Synergistic Role of Iron Regulatory Protein 1 and FBXL5 in Coordinating Iron Metabolism During Cell Proliferation
4:45 pm   Elizabeth A. Leibold: Iron Regulatory Protein 2 Regulates Insulin Production in Pancreatic β-Cells through Iron-Mediated Translation
5:00 pm – 6:00 pm Keynote lecture (chair: Tricia Kiley)
Tracey Rouault: Recent progress on iron sulfur proteins, ubiquitous and indispensable contributors to metabolism in all kingdoms of life

7:00 pm – 9:30 pm Banquet: (buffet style Tripp Commons)
9:00 pm – 11:00 pm Cash bar on Sunset Deck-Upper

Sunday, June 3, 2018: departure

Organizers

John Markley

Patricia Kiley

Speakers

Confirmed speakers

Lucia Banci Italy
David Barondeau USA
Frédéric Barras France
Squire Booker USA
Joan Broderick USA
Miroslav Cygler Canada
Dennis Dean USA
Brian Hoffmann USA
Jim Imlay USA
Nick LeBrun UK
Roland Lill Germany
Silke Leimkühler Germany
Sandrine Ollagnier France
Wayne Outten USA
Jaroslaw Marszalek Poland
Deborah Perlstein USA
Hélène Puccio France
Tracey Rouault USA
Nicolas Rouhier France
Jared Rutter USA
Lance Seefeldt USA
Yasuhiro Takahashi Japan
Dennis Winge USA

Additional speakers
20 submitted abstracts will be promoted to talks

Location, Lodging and Excursions

Location: Memorial Union, UW–Madison campus

Lodging

University Housing
Chadbourne Hall Single occupancy room: $70.48/night per person (includes breakfast) Double occupancy room: $47.23/night per person* (includes breakfast) *To be paired with a preferred roommate, both parties must request the other person. If you select a double occupancy room and do not submit a roommate request, University Housing will pair a person with you.
Conveniently located in the southeast area of the University of Wisconsin-Madison campus, participants staying in University Housing can enjoy the close proximity to the Memorial Union (.3 miles / approximately 3 blocks), are within walking distance to a vibrant shopping and entertainment district and located on the city bus line. University Housing is in close proximity to the Gordon Dining and Event Center and Southeast Recreation Facility
Complimentary Wi-Fi and wired Internet access is available throughout the facility. Daily breakfast is provided in a nearby dining facility. Guests may utilize the 24-hour tech center, kitchen and laundry facilities. Each guest room is air conditioned and includes single beds, towels, washcloths, soap, a mini-refrigerator and daily housekeeping services (except Sundays).

This residence hall provides affordable accommodations with shared bathrooms, including private shower areas, on each floor. Take advantage of floor lounges to network with colleagues.The 24-hour desk serves your needs for check-in and checkout and offers a few irons, ironing boards and some recreation equipment during your stay.
Use this link to reserve a room.

Madison Concourse Hotel and Governors Club
Room Rate: single $149.00/night and double $159.00/night
To make a reservation at the Madison Concourse Hotel Follow this link. Please make all reservations by Sunday, April 30, 2018, in order to receive the discounted rate.

The Madison Concourse Hotel and Governors Club is located in the heart of downtown Madison. Guests can walk to dozens of restaurants and shops. The hotel offers an indoor parking garage. The current rate is $10 per night. Additional parking is available across the street at the State Street Capitol ramp (214 N. Carroll Street). Please be advised that our parking garage has a low clearance and may not accommodate larger vehicles.
A complimentary airport shuttle is available to and from Dane County Regional Airport to all hotel guests. Please use the courtesy phone in the baggage claim area (located between Carousels 1 and 2, near Door 5) to let us know that you have your luggage and are ready to be picked up. The shuttle pick-up area is located outside baggage claim, Door 5. Please make a reservation at the Front Desk for your return trip to the airport. The airport is 5 miles from the hotel.

The Graduate
Room Rate: $149.00/night
To make a reservation call the hotel at 608.257.4391 or 800.589.6285. Please let them know you are part of the “Steenbock Symposium” group when making your reservation. Please make all reservations by Wednesday, April 18, 2018, in order to receive the discounted rate. You may also book online here.
The Graduate Madison is located in the heart of downtown Madison on the University of Wisconsin campus, steps from State Street dining and shopping. As a guest of the Graduate, you are invited to enjoy all of the following services and amenities: Portage Pi, coffee & juice bar with hand pies and healthy eats, The Madison Blind, rooftop bar with sweeping views of the Capitol and Lake Mendota, 24 hour fitness center, Complimentary shuttle service.
Parking is $12/night.

Doubletree Hotel
Room Rate: $149.00/night
To make a reservation at the Doubletree Hotel please call 608.251.5511 and use the code “SBS” or book online here. Please make all reservations by Saturday, May 5, 2018, in order to receive the discounted rate. You may also book online here.
The Doubletree Hotel Madison in the heart of downtown Madison, Wisconsin, at the eastern edge of the University of Wisconsin campus is nestled between the Lakes Monona and Mendota, within walking distance of the State Capitol, the UW Badgers’ Kohl Center, Camp Randall Stadium, and the eclectic State Street shopping and entertainment district. The Doubletree Hotel is about 10 minutes walking distance from site.

Spacious guest rooms, suites, and executive accommodations boast all the comforts of home and modern amenities such as complimentary wireless high-speed Internet access. Enjoy your favorite beverages and casual dining at the Badgerland Bar & Grill, serving breakfast, lunch, and dinner daily. Our hotel guests have full use of a heated indoor pool and whirlpool, outdoor patio, and a fitness room. We also offer complimentary shuttle service to and from the Dane County Regional Airport (15 minutes away), UW Campus, convention center, Alliant Energy Center, and downtown hospitals. Parking is complimentary on-site for hotel guests.

Lowell Center
Room Rate: $115/night/standard room & $124/night/deluxe room
To make a reservation at the Lowell Center, please call 608.256.2621 or 1.866.301.1753. Please make all reservations by Saturday, April 28, 2018, in order to receive the discounted rate. You may also book online.
Located just steps from Memorial Union, State Street shops and Madison’s vibrant Capitol Square, Lowell Center is where welcoming hotel accommodations—including comfortable guest rooms, an updated fitness center, inviting outdoor patios and the area’s largest indoor pool—and plush lounges designed for comfort and collaboration. Lowell Center is more than just a hotel – It’s where the Wisconsin Idea comes to stay.

Guests enjoy standard amenities like Keurig® coffee makers, mini refrigerators, Bath & Body Works® toiletries, flat screen TVs, complimentary wireless access, and the area’s most comfortable beds. It’s everything you need to unwind at the heart of the UW’s beautiful flagship campus. An expanded continental breakfast is included in the room rate. Guest parking is available on-site for $12/night (please make parking reservations in advance). There is an indoor swimming pool with sauna and fitness room.

Hampton Inn & Suites
Room Rate: $139/night
To make a reservations at the Hampton Inn & Suites Madison Downtown call 608.255.0360 and mention Steenbock Symposium. Please make all reservations by Friday, April 27, 2018, in order to receive the discounted rate. You may also book online here.
Located in the heart of downtown Madison and adjacent to the University of Wisconsin, the friendly Hampton Inn & Suites Madison/Downtown is within walking distance of shops, galleries, restaurants and nightspots. Stay here and enjoy easy access to museums, cultural destinations and other Madison, Wisconsin attractions. Stroll around the university’s attractive campus, shop or enjoy lunch downtown, catch a sporting event at the Kohl Center or spend time relaxing on Lake Monona or Lake Mendota.

Every inviting guest room and suite at this hotel in Madison, WI offers beautiful views of downtown Madison. Expect a range of modern amenities including a refrigerator, microwave and a clean and fresh Hampton bed®. Watch movies on the 42-inch LCD TV and stay connected at the ergonomic desk with free WiFi. Each morning, start your day with Hampton’s free hot breakfast, offering hot and cold favorites including fresh-baked waffles and hearty oatmeal with toppings. If you’re in a rush, grab a free Hampton On The Run® Breakfast Bag, available Monday-Friday.

AC Hotel Madison Downtown
Room Rate: $ 149.00/night
To make a reservation at AC Hotel call 608.286.1337 and mention Steenbock Symposium. Please make all reservations by noon on Saturday, April 28, 2018, in order to receive the discounted rate. You may also book online.
The AC Hotel Madison Downtown invites you to experience the perfect blend of classic style and modern comfort. Born in Spain and perfected in Europe’s most sophisticated cities, the hotel’s concept is elegant in its simplicity, providing everything that busy guests need for a comfortable, tranquil visit. Modern European rooms and suites offer sleek design and amenities including glass-enclosed showers, free high-speed Internet access, and ultra-comfortable bedding. Prepare for your day with breakfast at AC Kitchen, where you’ll enjoy signature baked croissants, artisan cured meats, sweet & savory egg tarts and Nespresso Coffee. Indulge our unique tapas and innovative cocktails at our AC Lounge. Gasp in awe at the breathtaking views of Madison from the rooftop restaurant & bar – Eno Vino Wine Bar & Bistro.