May 19, 2005 to May 22, 2005
This meeting will focus on Fe-S proteins, their unique and diverse biological functions, the highly conserved, complex machinery required for their biogenesis, and recent insights into their diverse structure. Recent advances in these emerging areas that impinge on biological systems from bacteria to humans, and serve as a forum for interaction amongst scientists investigating different aspects of Fe-S proteins. A goal of the meeting is to foster communication amongst participants of diverse backgrounds, including chemists, biochemists, molecular biologists and structural biologists.
Sessions will focus on
- Biogenesis of Fe-S proteins
- New Insights into Fe-S protein structure
- Fe-S proteins and human disease
- Roles of Fe-S clusters in regulation
- Novel enzymatic functions of Fe-S clusters
This is an accordion element with a series of buttons that open and close related content panels.
Schedule
Activities at the Pyle Center, 702 Langdon Street, Madison, Wisconsin
Thursday, May 19, 2005
4:30pm – 6:30pm – Reception and registration – Pick up conference materials.
Session #1 – Biogenesis of Fe-S Clusters – 1 – Chair, Patricia Kiley
6:45pm – Welcome
7:00pm – 7:30pm – Biochemical-Genetic Analysis of Fe-S Cluster Biosynthesis in Azotobacter vinelandii [PDF]
Dennis Dean – Virginia Tech
7:30pm – 8:00pm – The Roles of Chaperones HscA and HscB in Fe-S Protein Biogenesis [PDF]
Larry Vickery – U. California-Irvine
8:00pm – 8:20pm – Multiple Turnover 2Fe-2S Cluster Transfer Activity of IscA and IscU [PDF]
Francesco Bonomi – University of Milan
8:20pm – 8:40pm – Break
8:40pm – 9:10pm – Structure-Function and Evolutionary Aspects of Fe-S Cluster Assembly Systems [PDF]
Yasuhiro Takahashi – Osaka University
9:10pm – 9:30pm – The First Fe-S Cluster-Bound Crystal Structure of a Scaffold Protein [PDF]
Masato Nakai – Osaka University
9:30pm – 9:50pm – Iron Binding in IscA and Iron Delivery for the Biogenesis of Iron-Sulfur Clusters [PDF]
Huangen Ding – Louisiana State University
Friday, May 20, 2005
Session #2 – Biogenesis of Fe-S Clusters – II – Chair, Rick Eisenstein
8:30am – 9:00am – Biogenesis of Iron-Sulfur Proteins in Mitochondria and Cytosol of Eukaryotes [PDF]
Roland Lill – U. Marburg
9:00am – 9:30am – Cfd1p: A Cytosolic Fe-S Cluster Assembly Factor [PDF]
William Walden – Illinois-Chicago
9:30am – 9:50am – Ssq1-Jac1, a Specialized Chaperone System Involved in Biogenesis of Fe-S Cluster Containing Proteins in Yeast Mitochondria [PDF]
Jaroslaw Marszalek – University of Gdansk
9:50am – 10:15am – Break
10:15am – 10:45am – Mammalian Iron-Sulfur Biogenesis in Mitochondria and Cytosol [PDF]
Tracey Rouault – NIH
10:45am – 11:15am – The SUF Machinery in the Iron-Sulfur Cluster Biosynthesis [PDF]
Sandrine Ollagnier-de Choudens – Grenoble
11:15am – 11:35am – Analysis of Fe-S Cluster Formation in Plant Chloroplasts [PDF]
Marinus Pilon – Colorado State
11:35am – 11:55am – Analysis of the Heteromeric CsdA-CsdE Cysteine Desulfurase, Assisting Fe-S Biogenesis in Escherichia coli [PDF]
Beatrice Py – UPR-CNRS
12:00pm – 1:30pm – Lunch
1:30pm – 4:15pm – Poster Session 1
The presenters are those on the odd numbered pages of the abstract book.
Session #3 – The Role of Fe-S Clusters in Friedreich Ataxia – Chair, Elizabeth Craig
4:30pm – 5:00pm – Frataxin, Iron, and Oxygen [PDF]
Andrew Dancis – U. Penn
5:00pm – 5:30pm – Mouse and Cellular Models for Friedreich Ataxia:Consequences of Frataxin Deficiency [PDF]
Helene Puccio – Université Louis Pasteur
5:30pm – 5:50pm – Iron Binding and Delivery by Frataxin [PDF]
Timothy Stemmler – Wayne State University
5:50pm – 6:10pm – CyaY: Characterization of Iron Binding [PDF]
Salvatore Adinolfi – The Ridgeway
6:10pm – 6:30pm – Frataxin Deficiency Alters the Heme Pathway and a Homolog of a Yeast Metallochaperone in Mammalian Cells [PDF]
Gino Cortopassi – UC-Davis
6:30pm – Dinner – Dinner on your own. Independent evening activities.
Saturday, May 21, 2005
Session #4 – Novel Functions of Fe-S Clusters – Chair, Eckard Münck
8:30am – 9:00am – Chemical Approaches to Complex Heterometal Sites in Biology [PDF]
Richard Holm – Harvard
9:00am – 9:30am – Roles for [4Fe-4S] Clusters in the Repair of Damaged DNA Bases [PDF]
Sheila David – U. Utah
9:30am – 10:00am – Site-Specific Reactivity of [4Fe-4S] Clusters in Disulfide Reductases and Radical SAM Enzymes [PDF]
Michael K. Johnson – U. Georgia
10:00am – 10:30am – Break
10:30am – 11:00am – Iron-Sulfur Clusters in AdoMet-mediated Radical Chemistry [PDF]
Joan Broderick – Michigan State
11:00am – 11:30am – Biosynthesis of the Lipoyl Cofactor. Understanding Sulfur Insertion into Unactivated Alkanes [PDF]
Squire Booker – Penn State
11:30am – 11:50am – A Role for Iron-Sulfur Cluster Assembly and Repair in Biotin Biosynthesis [PDF]
Joseph Jarrett – University of Pennsylvania
12:00pm – 1:30pm – Lunch
1:30pm – 4:15pm – Poster Session 2
The presenters are those on the even numbered pages of the abstract book.
Session #5 – The Role of Fe-S Clusters in Stress and Human Disease – Chair, Claire Kennedy
4:30pm – 5:00pm – Iron-Sulfur Clusters Confer Vulnerability to Oxidative Stress [PDF]
James Imlay – U. Illinois
5:00pm – 5:30pm – Crystal Structure of the Aconitase Form of Human IronRegulatory Protein 1 [PDF]
Anne Volbeda – IBS Grenoble
5:30pm – 5:50pm – Enhanced NO Sensitivity of the Fe-S Cluster inPhosphomimetic Mutants of IRP1/c-aconitase [PDF]
Kathryn Deck – University of Wisconsin-Madison
5:50pm – 6:10pm – Iron Homeostasis Under Stress: Fe-S Cluster Biosynthesis and the suf Pathway in E. coli [PDF]
Wayne Outten – University of South Carolina
6:10pm – 6:30pm – Coordinating Expression of Fe-S Biogenesis Pathways in Escherichia coli [PDF]
Jennifer Giel – University of Wisconsin-Madison
6:30pm – Reception
7:30pm – Banquet
Sunday, May 22, 2005
Session #6 – Structural Aspects of Fe-S Clusters – Chair, Helmut Beinert
8:30am – 9:00am – From Madison to Grenoble and Back: Riding Ferredoxins Through Iron-Sulfur Territory [PDF]
Jacques Meyer – Grenoble
9:00am – 9:30am – Characterizing the Invisible: EPR and ENDOR Studies of Intermediates in N2 Reduction by Nitrogenase [PDF]
Brian Hoffman – Northwestern
9:30am – 9:50am – Living on Sulfur: 3D Architecture and Spectroscopy of the Iron-Sulfur Enzymes APS Reductase and Dissimilatory Sulfite Reductase [PDF]
Peter Kroneck – Fachbereich Biologie Universität Konstanz
9:50am – 10:15am – Break
10:15am – 10:45am – The Anatomy of AdoMet Radical Enzymes [PDF]
Catherine Drennan – MIT
10:45am – 11:15am – Lysine 2,3-aminomutase: Correlation of Reduction Potential for the [4Fe-4S] Center with the Crystal Structure
Perry Frey – University of Wisconsin-Madison
11:15am – 11:35am – The H cluster: A Light-Sensitive 6Fe Active Site in [Fe-Fe]-Hydrogenases [PDF]
Simon Albracht – University of Amsterdam
11:35am – 11:55am – Hydrogenase Structure, Function, and Expression [PDF]
John Peters – Montana State University
12:00pm – Box Lunch
Organizers
Sponsors
Dennis Dean
