May 20, 2004
The Department of Biochemistry at the University of Wisconsin has been an incredible breeding place for two different routes of scientific inquiry. The first path is exemplified by an extremely focused study of one particular problem probing ever deeper into its intricacies. The second model leads to diversification in which one line of study, while continuing to dig deeply, is primarily manifested by the addition of new areas of inquiry usually through the export of shared techniques but also through the recognition of underlying commonalities.
This Steenbock Symposium will exemplify deep scientific diversification. The Reznikoff lab initiated its work studying the molecular biology of bacterial gene regulation. It diversified into genomics and to studying the transposon structures that carried genes whose expression was being analyzed. This led to the analysis of transposition that in turn linked to mechanistically similar phenomena such as retroviral integration. In addition, those who had been trained in the laboratory moved into incredibly diverse fields such as RNA metabolism, gene silencing, DNA replication, membrane embedded functions and technology development. All of these and more will be highlighted at the 30th Steenbock Symposium.
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Speakers
Chris Adams – University of Wisconsin-Madison
Single Molecule Investigations of Tn5 Transposase – DNA Interactions
Brandon Ason – University of Wisconsin-Madison
Tn5 transposase as a target identifies compounds that inhibit HIV integration in
cells
Wayne Barnes – Washington University
Hot Start, Fidelity and Cloning Improvements for PCR
Blake W. Buchan – CESG, University of Wisconsin-Madison
High-throughput production of selenomethionine-labeled proteins in 2-liter PET bottles using an auto-inducing medium
Brendan Burns – CESG, University of Wisconsin-Madison
Screening and quantification methods for high-throughput production of unlabeled and labeled soluble Arabidopsis thaliana proteins in Escherichia coli
Mike Chandler – Institut d’Exploration Fonctionnelle des Génomes – France
Emerging Perspectives on the Transfer of Antibiotic Resistance
Nancy Craig – Johns Hopkins
Bug Transposons
Julian Davies – Univ. of British Columbia
Antibiotics, Gene Expression, and the Meaning of Life
Mike Fiandt – Epicentre
Transposon-mediated Rescue Cloning of Unidirectional Deletion Libraries From Either End of Any Target DNA
Jeffrey Gardner – University of Illinois- Urbana
Studies on the Conjugative Transposon CTn DOT
Richard Gradman – University of Wisconsin-Madison
Analysis of a Tn5 Insertion Library in MG1655
Carol Gross – UCSF
Stress Signaling Pathways
David B. Haniford – University of Western Ontario
The Impact of Host Factors on Tn10 Transposition: The Story Unfolds
Daria J. Hazuda – Merck Research Labs
Pyrophosphate Mimetics: a Mechanism Based Approach to Antiviral Drug Discovery
Wolfgang Hillen – Lehrstuhl Mikrobiologie
Gene Regulation by Tetracyclines: Mechanisms and Applications
Alik Honigman – The Hebrew University – Israel
CREB Hypoxia and Cancer
Lianna Johnson – UCLA
Gene silencing in Arabidopsis
Reid Johnson – David Geffen School of Medicine at UCLA
Architecture of the Hin synaptic complex before and after DNA exchange
Chinghai Kao – Indiana University
HoxB-13 in Prostate and Colorectal Cancer Development
Anna Karls – University of Georgia
Site-specific Recombination and Transposition Mediated by the NovelPiv/MooV DNA Recombinases
Russel Karls – University of Georgia
A Possible Role for Sigma Factor C in Mycobacterium tuberculosis Latency
Mark Krebs – Illinois State University
Bacteriorhodopsin Biogenesis: from Polypeptide to Membrane Crystal
Maria Mendez Lago – University of Wisconsin-Madison
Transposon-based innovative method for sequencing highly repetitive heterochromatic DNA in BAC/oriV clones.
V. A. Lanzov – Nuclear Physics Institute Petersburg, Russia
Molecular basis and biological reasons of hyper-recombinogenic activity of Pseudomonas aeruginosa RecA protein
Lisa Mahnke – Washington University School of Medicine
HIV-2 Vpx: Modeling and Probing Stucture/Function
John F Marko – University of Illinois-Chicago
Micromechanical study of proteins interacting with single DNA molecules
Lynne Maquat – Univ. of Rochester
Nonsense-mediated mRNA decay in mammalian cells: Splicing-dependent degradation that occurs 5′-to-3′ and 3′-to-5′ as a consequence of a “pioneer” round of translation
Patrice Nordmann – Dept. Bacteriology-Virology
Genetics as a source of emerging resistance to antibiotics
Martha Peterson – Univ. of Kentucky
RNA Processing Regulation of Immunoglobulin Gene Expression
Kathleen Postle – Washington State Univ.
Shuttling between Membranes, a New Energy Transduction Paradigm in Gram Negative Bacteria
William Reznikoff – University of Wisconsin-Madison
Tn5 transposase as a surrogate for HIV-1 integrase in drug screens
Steven Rothstein – University of Guelph
Is there a role for Genomics in Crop Improvement?
Anna Marie Skalka – Fox Chase Cancer Center
Suffering the Slings and Arrows: Role of Host Cell Functions in Post-Integration Repair
Sally Twining – Medical College of Wisconsin-Milwaukee
Role Of The Reactive Site Loop In The Function Of Maspin
Roger Wartell – Georgia Institute of Technology
Identifying RNA binding sites on the E. coli Hfq protein
Michael Weinreich – Van Andel Research Institute
The NAD+-dependent Sir2p Histone Deacetylase is a Negative Regulator of Chromosomal DNA Replication
Robert Wells – Texas A&M Univ.
Recombination as an Effective Mechanism for Genetic Instabilities of Triplet Repeat Sequences
Kelly Winterberg – University of Wisconsin-Madison
In vivo Microarray Screening to Identify Uropathogenic Escherichia coli (UPEC) Genes Involved in Early Colonization and Infection in Murine Urinary Tract Infections
Lewis V. Wray, Jr. – Boston Univ.
Dual roles of Bacillus subtilis glutamine synthetase
Jerry Yin – University of Wisconsin-Madison
Memory Formation in Drosophila